Phuah Lab

Chia Ling Phuah, MD

Chia Ling Phuah has a diverse scientific and educational background that spans molecular, systems, and computational neuroscience with a research portfolio that includes active projects in genetics, neuroimaging, artificial intelligence, and machine-learning. Her research focuses on advancing the understanding of how white matter injury influences cognitive impairment, neurodegeneration, and stroke using computational approaches for deriving novel biomolecular and imaging phenotypes, and leveraging multi-modal data from large, well-characterized cohorts. She leads research on elucidating disease mechanisms in cerebral small vessel disease using machine-learning and neuroimaging genetics (supported by NIH K23 NS110927 and the American Heart Association), and identifying molecular and cognitive signatures of white matter injury in vascular cognitive impairment and AD-related dementias (supported by the CCAD New Vision Award).

Principal investigator

Chia-Ling Phuah, MD, MMSc

Chia-Ling Phuah, MD, MMSc

Associate Professor of Neurology

Medical school: University of Cambridge Residency: Mass General/Brigham Neurology Residency Fellowship: Mass General/Brigham Neurocritical Care


  • The relevance of rich club regions for functional outcome post-stroke is enhanced in womenThe MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium, Mar 2023, In: Human Brain Mapping. 44, 4, p. 1579-1592 14 p.Research output: Contribution to journal › Article › peer-review
  • Radiomics-Derived Brain Age Predicts Functional Outcome after Acute Ischemic StrokeBretzner, M., Bonkhoff, A. K., Schirmer, M. D., Hong, S., Dalca, A., Donahue, K., Giese, A. K., Etherton, M. R., Rist, P. M., Nardin, M., Regenhardt, R. W., Leclerc, X., Lopes, R., Gautherot, M., Wang, C., Benavente, O. R., Cole, J. W., Donatti, A., Griessenauer, C., Heitsch, L., & 36 othersHolmegaard, L., Jood, K., Jimenez-Conde, J., Kittner, S. J., Lemmens, R., Levi, C. R., McArdle, P. F., McDonough, C. W., Meschia, J. F., Phuah, C. L., Rolfs, A., Ropele, S., Rosand, J., Roquer, J., Rundek, T., Sacco, R. L., Schmidt, R., […]
  • White matter hyperintensity longitudinal morphometric analysis in association with Alzheimer diseaseStrain, J. F., Phuah, C. L., Adeyemo, B., Cheng, K., Womack, K. B., McCarthy, J., Goyal, M., Chen, Y., Sotiras, A., An, H., Xiong, C., Scharf, A., Newsom-Stewart, C., Morris, J., Benzinger, T. L. S., Lee, J-M. & Ances, B. M., 2023, (Accepted/In press) In: Alzheimer's and Dementia.Research output: Contribution to journal › Article › peer-review
  • Association of Data-Driven White Matter Hyperintensity Spatial Signatures with Distinct Cerebral Small Vessel Disease EtiologiesPhuah, C. L., Chen, Y., Strain, J. F., Yechoor, N., Laurido-Soto, O. J., Ances, B. M. & Lee, J. M., Dec 6 2022, In: Neurology. 99, 23, p. E2535-E2547Research output: Contribution to journal › Article › peer-review
  • Vascular endothelial-cadherin as a marker of endothelial injury in preclinical Alzheimer diseaseTarawneh, R., Kasper, R. S., Sanford, J., Phuah, C. L., Hassenstab, J. & Cruchaga, C., Dec 2022, In: Annals of Clinical and Translational Neurology. 9, 12, p. 1926-1940 15 p.Research output: Contribution to journal › Article › peer-review